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Key Largo is connected to the mainland in Miami-Dade County by two routes. The Overseas Highway, which is U.S. Highway 1, enters Key Largo at Jewfish Creek near the middle of the island and turns southwest. Card Sound Road connects to the northern part of Key Largo at Card Sound Bridge and runs eastward to connect with County Road 905, which runs southwest and joins U.S. 1 at about mile marker 106. These routes originate at Florida City on the mainland. Key Largo is a popular tourist destination and calls itself the "Diving Capital of the World" because the living coral reef a few miles offshore attracts thousands of scuba divers and sport fishing enthusiasts. Key Largo's proximity to the Everglades also makes it a premier destination for a Florida keys Fishing Vacation including kayakers and eco tourists.

Islamorada, a "Village of Islands," is an incorporated village in Monroe County, Florida, United States. It is located on the islands of Tea Table Key, Lower Matecumbe Key, Upper Matecumbe Key, Windley Key and Plantation Key in the Florida Keys. The village was incorporated on November 4, 1997. Prior to this date, Islamorada was only considered to be on the island of Upper Matecumbe Key. Islamorada is know for its fishing vacations because of the easy access to the Florida Bay and the Atlantic Ocean. From Bonefish to Sailfish Islamorada is a top location for a fishing vacation.

Marathon is a city on Knight's Key, Boot Key, Key Vaca, Fat Deer Key, Long Point Key, Crawl Key and Grassy Key islands in the middle Florida Keys, in Monroe County, Florida, in the United States. Big Pine Key is a census-designated place and unincorporated community in Monroe County, Florida, on an island of the same name in the Florida Keys.

Key West is a city in Monroe County, Florida, United States. The city encompasses the island of Key West, the part of Stock Island north of U.S. 1 (the Overseas Highway) (east), Sigsbee Park (north, originally known as Dredgers Key), Fleming Key (north), and Sunset Key (west, originally known as Tank Island). Both Fleming Key and Sigsbee Park are part of Naval Air Station Key West and are inaccessible by civilians. Key West is the county seat of Monroe County. Key West is known as the southernmost city in the Continental United States. It is also the southern terminus of U.S. 1, State Road A1A, the East Coast Greenway and before 1935, the Florida East Coast Railway. Key West is 129 miles (207 km) southwest (229.9 degrees) of Miami, Florida, (about 160 driving miles) and 106 miles (170 km) north-northeast (21.2 degrees) of Havana Cuba. Cuba, at its closest point, is 94 miles south. Key West is a seaport destination for many Florida Keys Vacation passenger cruise ships. The Key West International Airport provides airline service. Hotels and guest houses are available for lodging. Naval Air Station Key West is an important year round training site for naval aviation due to the superb weather conditions. It is also a reason the city was chosen as the Winter White House of President Harry S. Truman. The central business district primarily comprises Duval Street, and includes much of the northwest corner of the island along Whitehead, Simonton, Front, Greene, Caroline, and Eaton Streets and Truman Avenue. The official city motto is "One Human Family." When you think of a Florida Keys Fishing and family vacation, what thoughts come to mind? Looking for family togetherness plus time to relax and leave the hassles of everyday life behind? If fun as a family is your goal with time for adult relaxation, seek out a kid's friendly vacation spot with attractions that appeal to both adults and children. An all-inclusive resort is one of the best ways to bypass family vacation pitfalls for your Florida Keys Fishing Vacations. Such family-oriented resorts are designed to provide fun and excitement for children as well as time for adult pursuits.